SIRT1 plays key role in chronic myeloid leukemia to aid persistence of leukemic stem cells

(University of Alabama at Birmingham) Patients with chronic myeloid leukemia are treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure. In a study published in the Journal of Clinical Investigation, researchers show how the stress-responsive protein SIRT1 plays important roles in maintaining the regenerative potential of CML le...